Balki Bartokomous, a sheepherder from the small Mediterranean Greek-like island of Mypos, travels to the United States in search of his relatives. He finds his cousin, Larry Appleton - who has recently 'escaped' from his large-sized family and is reveling in the unaccustomed luxury of having his own room to himself. They end up sharing accommodation in Larry's apartment - even though the two cousins could not be more dissimilar. For, while Larry is panicky, hyperventilative, business-like and mercenary - Balki is placid, unharried, sunny-natured and idealistic.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

Star softball player, Lisa, has just been cut from the national team; Scholarly business man, George, has just been indicted from his father's company. With everything that they know in their lives taken from them, Lisa and George attempt to find romance. Lisa's potential boyfriend, Matty, however, is as clueless and perpetually single as they come, and George's girlfriend just dumped him. A chance hook-up through mutual friends, Lisa and George may be able to form a friendship, or more, that can help them climb out of the piles of lemons that life has handed to them.